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Pediatric heart transplantation in the current era

D’Addese, Lauraa; Joong, Annab; Burch, Michaela; Pahl, Elfriedeb

doi: 10.1097/MOP.0000000000000805
CARDIOVASCULAR MEDICINE: Edited by Daniel Bernstein

Purpose of review To provide an international perspective and current review of pediatric heart transplantation (PHTx).

Recent findings Waitlist survival and long-term outcomes in PHTx continue to improve. Strategies to maximize donor pool utilization include ABO incompatible listing for infants and expanded donor-to-recipient weight ranges. However, there is a high degree of practice variation internationally, from listing strategies and donor acceptance practices to chronic immunosuppression regimens, long-term graft surveillance, and consideration for retransplantation.

Summary Common indications for PHTx include end-stage congenital heart disease and cardiomyopathy. Current median graft survival among PHTx recipients ranges from 13 to 22 years. Common morbidities include infection, rejection, renal dysfunction, coronary allograft vasculopathy, and posttransplant lymphoproliferative disease. International registry data, collaborative initiatives to standardize management, and multicenter studies continue to improve knowledge and advancement of the field.

aCardiology Department, Great Ormond Street Hospital NHS Foundation Trust, London, UK

bDivision of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital, Chicago, Illinois, USA

Correspondence to Laura D’Addese, MD, Cardiology Department, Great Ormond Street Hospital NHS Foundation Trust, Great Ormond Street, London WC1N 3JH, UK. Tel: +44 749 389 2096; e-mail: Laura.D’

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