Retinitis pigmentosa recent advances and future directions in diagnosis and managementFahim, AbigailCurrent Opinion in Pediatrics: December 2018 - Volume 30 - Issue 6 - p 725–733 doi: 10.1097/MOP.0000000000000690 GENETICS: Edited by Nathaniel H. Robin Abstract Author InformationAuthors Article MetricsMetrics Purpose of review Retinitis pigmentosa is a group of genetically diverse inherited blinding disorders for which there are no treatments. Owing to recent advances in imaging technology, DNA sequencing, gene therapy, and stem cell biology, clinical trials have multiplied and the landscape is rapidly changing. This review provides a relevant and timely update of current trends and future directions for the diagnosis and management of this disease. Recent findings This review will highlight the use of retinal imaging to measure progression of disease, next-generation sequencing for genetic diagnosis, the use of electronic retinal implants as well as noninvasive digital low-vision aids, and the current state of preclinical and clinical research with gene therapy and cell-based therapies. Summary Retinitis pigmentosa has historically been an untreatable condition. Recent advances have allowed for limited improvement in visual outcomes for select patients. Retinal degenerative disease is on the cutting edge of regenerative medicine. Gene therapy and stem cell therapeutic strategies are currently under investigation and are expected to radically impact management of inherited retinal disease in the coming years. Video abstract http://links.lww.com/MOP/A33. Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA Correspondence to Abigail Fahim, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48109, USA. Tel: +1 734 936 8120; e-mail: firstname.lastname@example.org Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.co-pediatrics.com). Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.