DERMATOLOGY: Edited by Joyce M.C. TengClinical implications of new mechanistic insights into atopic dermatitisLeung, Donald Y.M. Author Information Edelstein Family Chair of Pediatric Allergy-Immunology, National Jewish Health, Denver, Colorado, USA and Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The 2nd Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Correspondence to Donald Y.M. Leung, MD, PhD, National Jewish Health, 1400 Jackson Street, Room K926i, Denver, CO 80206, USA. Tel: +1 303 398 1379; fax: +1 303 270 2182; e-mail: [email protected] Current Opinion in Pediatrics: August 2016 - Volume 28 - Issue 4 - p 456-462 doi: 10.1097/MOP.0000000000000374 Buy Metrics Abstract Purpose of review The review will examine recent advances in our understanding of atopic dermatitis and how these mechanisms provide a framework for new approaches to the management of this common skin disease. Recent findings The mechanisms by which epithelial skin barrier and immune responses contribute to the complex clinical phenotypes found in atopic dermatitis are being elucidated. Atopic dermatitis often precedes food allergy because reduced skin barrier function allows environmental food allergens to penetrate the skin leading to systemic allergen sensitization. There is increasing evidence that atopic dermatitis is a systemic disease. New treatments are focused on intervention in polarized immune responses leading to allergic diseases. This includes antagonism of IL-4 and IL-13 effects. Prevention strategies involve maintaining normal skin barrier function with emollients to prevent allergens and microbes from penetrating the skin. Summary Recent work on the pathogenesis of atopic dermatitis has important implications for its clinical management, including the development of effective barrier creams and biologicals targeting specific polarized immune pathways resulting in skin inflammation. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.