The pediatric heart network: meeting the challenges to multicenter studies in pediatric heart diseaseBurns, Kristin M.; Pemberton, Victoria L.; Pearson, Gail D.Current Opinion in Pediatrics: October 2015 - Volume 27 - Issue 5 - p 548–554 doi: 10.1097/MOP.0000000000000260 CARDIOVASCULAR MEDICINE: Edited by Daniel Bernstein Buy Abstract Author InformationAuthors Article MetricsMetrics Purpose of review Because of the relatively small numbers of pediatric patients with congenital heart disease cared for in any individual center, there is a significant need for multicenter clinical studies to validate new medical or surgical therapies. The Pediatric Heart Network (PHN), with 15 years of experience in multicenter clinical research, has tackled numerous challenges when conducting multicenter studies. Recent findings This review describes the challenges encountered and the strategies employed to conduct high-quality, collaborative research in pediatric cardiovascular disease. Summary Sharing lessons learned from the PHN can provide guidance to investigators interested in conducting pediatric multicenter studies. National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA Correspondence to Gail D. Pearson, MD, ScD, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, 6701 Rockledge Drive, Room 8132, Bethesda, MD 20892, USA. Tel: +1 301 435 0477; e-mail: email@example.com Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.