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Rampersad, Avind; Mukundan, Deepa

doi: 10.1097/MOP.0b013e32832130d2
Office pediatrics: Edited by Henry H. Bernstein

Purpose of review A comprehensive review of the current advances in the field of fever in children is presented.

Recent findings Clinical and diagnostic predictors of serious disease in a child with fever are still being explored for early diagnosis so that therapy could be appropriately targeted. Host susceptibility and immune response are making strides in the understanding of disease pathogenesis and in identifying the causes of fever. Measurement of fever as a screening tool, a review of the efficacy of antipyretics alone or in combination, and finally a global perspective of fever have been discussed through a review of some of the publications in the past 18 months.

Summary Better markers are required to predict serious bacterial infection in a child with fever. Clinical application of the host immune response in the diagnosis and management of fever is the direction of the future.

Department of Pediatrics, University of Toledo College of Medicine, Toledo, Ohio, USA

Correspondence to Deepa Mukundan, MD, FAAP, University of Toledo College of Medicine, Department of Pediatrics, 2222 Cherry Street, Suite 2300, Toledo, Ohio 43608, USA Tel: +1 419 251 8039; fax: +1 419 251 7715; e-mail:

© 2009 Lippincott Williams & Wilkins, Inc.