Therapeutics and toxicology: Edited by Robert O. WrightFish consumption, methylmercury and child neurodevelopmentOken, Emilya; Bellinger, David CbAuthor Information aDepartment of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Healthcare, USA bDepartment of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA Correspondence to Emily Oken, MD, MPH, Department of Ambulatory Care and Prevention, 133 Brookline Avenue, Boston, MA 02215, USA Tel: +1 617 509 9835; fax: +1 617 509 9853; e-mail: [email protected] Current Opinion in Pediatrics: April 2008 - Volume 20 - Issue 2 - p 178-183 doi: 10.1097/MOP.0b013e3282f5614c Buy Metrics Abstract Purpose of review To summarize recent evidence regarding associations of early life exposure to mercury from maternal fish consumption during pregnancy, thimerosal in vaccines and dental amalgam with child neurodevelopment. Recent findings Recent publications have built upon previous evidence demonstrating mild detrimental neurocognitive effects from prenatal methylmercury exposure from maternal fish consumption during pregnancy. New studies examining the effects of prenatal fish consumption as well as methylmercury suggest there are benefits from prenatal fish consumption, but also that consumption of fish high in mercury should be avoided. Future studies incorporating information on both the methylmercury and the docosahexaenoic acid contained within fish will help to refine recommendations to optimize outcomes for mothers and children. Additional recent studies have supported the safety of vaccines containing thimerosal and of dental amalgam for repair of dental caries in children. Summary Exposure to mercury may harm child development. Interventions intended to reduce exposure to low levels of mercury in early life must, however, be carefully evaluated in consideration of the potential attendant harm from resultant behavior changes, such as reduced docosahexaenoic acid exposure from lower seafood intake, reduced uptake of childhood vaccinations and suboptimal dental care. © 2008 Lippincott Williams & Wilkins, Inc.