PulmonologyAge-related changes in the asthmatic phenotype in childrenHorner, Caroline C; Strunk, Robert C Author Information Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Missouri, USA Correspondence to Robert C. Strunk, MD, Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, 1 Children's Place, St Louis, MO 63110, USA Tel: +1 314 454 2694; fax: +1 314 454 2515; e-mail: [email protected] Current Opinion in Pediatrics: June 2007 - Volume 19 - Issue 3 - p 295-299 doi: 10.1097/MOP.0b013e32809913a2 Buy Metrics Abstract Purpose of review To review the changes in the asthma phenotype as children progress from childhood into young adulthood. Recent findings Some children with asthma in the early school years improve symptomatically during adolescence and young adulthood, with less frequent remissions and increased relapse rates in those with severe symptoms. During remission of symptoms, lung function abnormalities, airway hyper-responsiveness, and airway inflammation often persist. New data from the Childhood Asthma Management Program cohort show progression of lung function abnormalities during adolescence. Summary Most children with persistent asthma have persistent disease as adults, and lung function abnormalities continue to progress as these children age. © 2007 Lippincott Williams & Wilkins, Inc.