HEAD AND NECK ONCOLOGY: Edited by Cesare Piazza and Alberto PadernoIndications of external beams radiation for thyroid cancerRoukoz, Camillea,b; Gregoire, Vincenta Author Information aRadiation Oncology Department, Centre de Lutte Contre le Cancer Léon Bérard, Lyon, France bDepartment of Radiation Oncology, Hôtel-Dieu de France University Hospital, Saint Joseph University, Beirut, Lebanon Correspondence to Vincent Gregoire, MD, PhD, Hon FRCR (IE), Hon FRCR (UK), Centre Léon Bérard, Département de Radiothérapie, Rue Laennec 28, 69008 Lyon, France. Tél: +04 69 85 62 53; fax: +04 78 78 51 40; e-mail: [email protected] Current Opinion in Otolaryngology & Head and Neck Surgery: April 2022 - Volume 30 - Issue 2 - p 137-144 doi: 10.1097/MOO.0000000000000795 Buy Metrics Abstract Purpose of review The use of external beam radiation therapy (EBRT) for the treatment of the different histologic subtypes of thyroid cancer is a matter of debate. This article provides an up-to-date review on the current evidence concerning the benefits of EBRT in thyroid cancer in specific indications. Recent findings Based on retrospective studies, adjuvant EBRT lessens the risk of locoregional recurrence in locally advanced differentiated thyroid cancer (DTC) and medullary thyroid cancer (MTC) with high-risk features. The effect of EBRT on overall survival remains uncertain. EBRT should also be part of the multimodality treatment in anaplastic thyroid cancer (ATC), as it improves survival rates in incompletely resected ATC. Summary The role of EBRT in thyroid cancer remains unclear. To date, no randomized control studies are available. Retrospective data showed improved outcomes in patients with high-risk features for locoregional recurrence. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.