Purpose of review
The aim of this article is to identify and describe the relationship between chronic rhinosinusitis
(CRS) and comorbid depression
, including the patient factors that may increase the risk of depression
. The impact of comorbid depression
on quality of life, response to treatment and healthcare utilization will also be assessed.
CRS is associated with a significantly increased prevalence of depression
, where 9–26% of patients with CRS will have physician-diagnosed depression
. An additional 40% will have undiagnosed depression
that can be identified through screening tools. Patients without polyps are more likely to experience comorbid depression
, as are patients with significant sleep dysfunction, olfactory dysfunction, and pain. CRS symptoms do improve with medical and surgical therapy in depressed patients, though baseline and posttreatment scores are worse. A similar degree of benefit from therapy is seen in both depressed and nondepressed patients. CRS treatment does seem to improve depression
, whereas the effect of depression
specific therapy is unknown. Depressed patients have a significantly larger economic burden because of their increased healthcare utilization and productivity losses.
is a highly prevalent and impactful comorbidity in patients with CRS. Increased awareness of this relationship may improve patients’ overall quality of care.