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Oncologic management of sinonasal undifferentiated carcinoma

Tyler, Matthew A.a; Holmes, Brittanyb; Patel, Zara M.a

Current Opinion in Otolaryngology & Head and Neck Surgery: February 2019 - Volume 27 - Issue 1 - p 59–66
doi: 10.1097/MOO.0000000000000513
NOSE AND PARANASAL SINUSES: Edited by Samuel S. Becker and Nithin D. Adappa

Purpose of review This article reviews the latest treatment paradigms in sinonasal undifferentiated carcinoma (SNUC).

Recent findings The aggressive biology and associated advanced presentation of SNUC make successful treatment a challenge shared across medical specialties. Still, studies reporting outcomes in SNUC indicate that an aggressive treatment strategy consisting of surgery, radiation and chemotherapy offers the best chance of prolonged survival.

Summary Successful treatment of SNUC requires highly specialized care at tertiary cancer treatment facilities. A better understanding of the biology of the disease coupled with increasing outcome reporting will lead to optimized treatment regimens.

aDepartment of Otolaryngology-Head and Neck Surgery

bDepartment of Pathology, Stanford University School of Medicine, Stanford, California, USA

Correspondence to Zara M. Patel, MD, Assistant Professor, Director of Endoscopic Skull Base Surgery, Rhinology - Sinus and Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch, Stanford, CA 94305, USA. Tel: +1 650 723 5651; e-mail:

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