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Regeneration of the mammalian inner ear sensory epithelium

Wei, Dongguang; Yamoah, Ebenezer N

Current Opinion in Otolaryngology & Head and Neck Surgery: October 2009 - Volume 17 - Issue 5 - p 373–380
doi: 10.1097/MOO.0b013e328330345b
Hearing science: Edited by Rodney C. Diaz
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Purpose of review This review will focus on ‘self-repair’ of the mammalian inner ear sensory epithelium, including recruiting the in-situ proliferation and differentiation of endogenous cells at the damaged site and the autologous transplantation

Recent findings Self-repair refers to a favorable structural and functional outcome of damaged inner ear sensory epithelium. Our advanced ability of manipulating the fate of inner ear sensory cells makes in-situ proliferation a possible candidate of hearing restoration. A practical alternative of the unavoidable immune rejection is to introduce autologous cells. Ependymal cells, induced pluripotent stem cells, and olfactory neuroepithelial cells have been recognized as promising sources, which will spur ongoing efforts to evaluate these new cell sources for cell replacement therapy.

Summary Further exploration of the innate advantages of in-situ proliferation and use of novel cell sources for autologous transplantation may serve as rehearsals for clinical trials in the near future.

Center for Neuroscience, Program in Communication Science, Department of Anesthesiology and Pain Medicine, University of California, Davis, California, USA

Correspondence to Ebenezer N. Yamoah, Department of Anesthesiology and Pain Medicine, Center for Neuroscience, Program in Communication Science, University of California, Davis, 1544 Newton Ct. Davis, CA 95618, USA Tel: +1 530 754 6630; e-mail: enyamoah@ucdavis.edu

© 2009 Lippincott Williams & Wilkins, Inc.