Review of the role of aquaporins in inner ear homeostasis and potential role in the pathogenesis of Meniere's disease.
Recent findings include the immunolocalization of aquaporins in the inner ear of mouse, rat, and human to cell types that are likely to undergo high ionic perturbances (e.g. potassium flux) and to putative areas of endolymph resorption or cycling.
The expression of aquaporins and related proteins in the human cochlea and vestibular periphery resembles the distribution found in animal models, suggesting a critical role of aquaporins in inner ear water homeostasis and their potential role in the pathogenesis of Meniere's disease.
aDepartment of Neurology, USA
bDivision of Head and Neck Surgery, David Geffen School of Medicine at the University of California, Los Angeles, USA
Correspondence to Akira Ishiyama, MD, Surgery Department (Division of Head and Neck), David Geffen School of Medicine at UCLA, CHS-62-132, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA fax: +310 206 1393; e-mail: email@example.com
This work was supported by National Institutes of Health grants AG09693-10, DC005224, 00140-02, and DC05187-01.