OCULOPLASTIC AND ORBITAL SURGERY: Edited by Richard C. AllenDiagnosis of enlarged extraocular muscles when and how to biopsyMombaerts, Ilsea; Rose, Geoffrey E.b,c; Verity, David H.b Author Information aDepartment of Ophthalmology, University Hospitals Leuven, Leuven, Belgium bMoorfields Eye Hospital cInstitute of Ophthalmology, London, UK Correspondence to Ilse Mombaerts, MD, PhD, Department of Ophthalmology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium. E-mail: [email protected] Current Opinion in Ophthalmology 28(5):p 514-521, September 2017. | DOI: 10.1097/ICU.0000000000000395 Buy Metrics Abstract Purpose of review To review current knowledge regarding diagnosis of nonthyroid orbital disorders with extraocular muscle enlargement. Recent findings Recent publications have focused on immunoglobulin G4-related disease as a possible cause of enlarged extraocular muscles, on patterns of strabismus that raise a clinical suspicion of intramuscular lymphoma, and on surgical techniques to access the muscles for tissue biopsy. Summary With enlarged extraocular muscles, features to distinguish between competing diagnostic possibilities are based on imaging in the context of history and clinical signs. Infraorbital nerve enlargement in the presence of muscle enlargement strongly favours a diagnosis of immunoglobulin G4-related disease and reactive lymphoid hyperplasia. As our understanding of minimally invasive orbital surgery evolves, the diagnostic focus is shifting toward earlier identification through muscle biopsy. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.