OCULAR MANIFESTATIONS OF SYSTEMIC DISEASE: Edited by John GonzalesPeripheral ulcerative keratitis due to systemic diseasesSura, Amol A.a; McCallum, Rex M.b Author Information aDepartment of Ophthalmology bDepartment of Medicine, Division of Rheumatology, Duke University, Durham, North Carolina, USA Correspondence to Amol A. Sura, MD, Department of Ophthalmology, Duke University, Durham, NC 27705, USA. Tel: +1 225 333 0026; e-mail: [email protected] Current Opinion in Ophthalmology 33(6):p 543-550, November 2022. | DOI: 10.1097/ICU.0000000000000895 Buy Metrics Abstract Purpose of review To discuss peripheral ulcerative keratitis, with a focus on the evaluation and management of associated systemic diseases. Recent findings Peripheral ulcerative keratitis (PUK) is a sight-threatening condition that is often defined by the presence of a crescent-shaped area of peripheral corneal thinning, an epithelial defect, and an inflammatory corneal infiltrate. It is highly associated with rheumatoid arthritis, systemic necrotizing vasculitides like granulomatosis with polyangiitis, and collagen vascular diseases like systemic lupus erythematosus. Undertreated PUK carries a risk of vision loss and premature death. Summary Multidisciplinary collaboration between the ophthalmologist, rheumatologist, and other consultants is required. Early and aggressive steroid-sparing therapy should be considered in cases due to noninfectious systemic disease. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.