OCULAR MANIFESTATIONS OF SYSTEMIC DISEASE: Edited by John A. GonzalesHistory through the eyes of a pandemicGraversen, Veronica Kona; Hamichi, Sophia Elb; Gold, Aaronb; Murray, Timothy G.bAuthor Information aRetina Health Center, Fort Myers bMurray Ocular Oncology and Retina, Miami, Florida, USA Correspondence to Veronica Kon Graversen, MD, Retina Health Center, 1567 Hayley Lane, Fort Myers, FL, 33907, USA. Tel: +1 239 202 1424; fax: +1 239 274 6610; e-mail: firstname.lastname@example.org Current Opinion in Ophthalmology: November 2020 - Volume 31 - Issue 6 - p 538-548 doi: 10.1097/ICU.0000000000000711 Buy Metrics Abstract Purpose of review This review provides a historic perspective of the impact that major pandemics have had on human and their relationship with ophthalmology. The novel coronavirus epidemic is also analyzed, highlighting the relevance of the eye as a possible source of transmission, infection, and prognosis for the disease. Results Smallpox is suspected to be present for more than 12 000 years. However, trachoma seems to be the first recorded ophthalmological infectious disease. The deadliest pandemics include the bubonic plague, smallpox, and Spanish flu. The CoVID-19 epidemic is still developing and measures need to be implemented to prevent further escalation of the crisis. Summary Understanding the current facts in light of earlier historical evidence may help us prepare better to minimize the spread of infections in the future. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.