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Ocular manifestations of dengue

Somkijrungroj, Thanapong; Kongwattananon, Wijak

Current Opinion in Ophthalmology: November 2019 - Volume 30 - Issue 6 - p 500–505
doi: 10.1097/ICU.0000000000000613

Purpose of review There are an increasing number of publications related to dengue ophthalmic manifestations and multimodality imaging related to dengue. This review summarizes the current literature, describe ocular manifestations, current using of ocular imaging/investigations, and management of ocular dengue.

Recent findings Ocular manifestations of dengue can be present in many stages of dengue fever including after the resolution of systemic disease. Most cases of ocular dengue will exhibit an improvement in vision spontaneously over time. Multimodal imaging such as optical coherence tomography, optical coherence tomography angiography, near-infrared imaging, and microperimetry plays an important role in the diagnosis, follow-up, quantitative measure, and help to understand the disease progression.

Summary Dengue fever can lead to a variety of ocular manifestations. The mechanisms underlying dengue-related ocular complications remain unclear. Immune-mediated mechanisms and direct viral invasion are thought to play an important role. Ophthalmologists should carefully assess patients with dengue-related ophthalmic disease because some patients may have poor visual acuity and exhibit refractoriness to treatment. Treatment with systemic corticosteroids may benefit those patients with poor presenting visual acuity, progressive ocular symptoms, and lesions involving the optic nerve and/or threatening the macula.

Vitreo-Retinal Research Unit, Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand

Correspondence to Thanapong Somkijrungroj, MD, Chief of Uveitis Unit, Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and Hospital, Pathum Wan, Bangkok 10330, Thailand. Tel: +66 86 366 4020; e-mail:

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