GLAUCOMA: Edited by Donald L. BudenzOptic disc hemorrhage in glaucoma pathophysiology and prognostic significanceKim, Ko Eun; Park, Ki HoAuthor Information aDepartment of Ophthalmology, Nowon Eulji Medical Center, Eulji University bDepartment of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Republic of Korea Correspondence to Dr Ki Ho Park, MD, PhD, Professor, Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea. Tel: +82 2 2072 2438; fax: +82 2 741 3187; e-mail: [email protected] Current Opinion in Ophthalmology: March 2017 - Volume 28 - Issue 2 - p 105-112 doi: 10.1097/ICU.0000000000000345 Buy Metrics Abstract Purpose of review This article reviews the recent findings with regard to the pathophysiology and clinical significance of optic disc hemorrhage in glaucoma. Recent findings Even though the pathophysiology of disc hemorrhage has been investigated in depth, its underlying mechanism remains unclear. The key disc hemorrhage mechanisms currently under discussion are mechanical vascular disruption and associated vascular susceptibilities. Recent technical advances in spectral-domain optical coherence tomography have yielded more compelling evidence of mechanical vascular disruption behind the pathogenesis of disc hemorrhage in glaucoma. Studies show that disc hemorrhage is associated with structural and functional glaucoma progression. Furthermore, recent findings suggest that disc hemorrhage can have different significances according to its location, recurrence, and associated underlying mechanism. Summary The underlying mechanism of disc hemorrhage is complex like that of glaucoma. The ongoing controversy respecting the role of disc hemorrhage as a risk factor for glaucoma progression notwithstanding, special attention entailing closer follow-up and/or treatment escalation is recommended for patients with disc hemorrhage. Further studies investigating the unrevealed pathogenesis of disc hemorrhage and its prognostic value in glaucoma are warranted. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.