Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Amblyopia update

new treatments

Vagge, Aldo; Nelson, Leonard B.

Current Opinion in Ophthalmology: September 2016 - Volume 27 - Issue 5 - p 380–386
doi: 10.1097/ICU.0000000000000293

Purpose of review This review article is an update on the current treatments for amblyopia. In particular, the authors focus on the concepts of brain plasticity and their implications for novel treatment strategies for both children and adults affected by amblyopia.

Recent findings A variety of strategies has been developed to treat amblyopia in children and adults. New evidence on the pathogenesis of amblyopia has been obtained both in animal models and in clinical trials. Mainly, these studies have challenged the classical concept that amblyopia becomes untreatable after the ‘end’ of the sensitive or critical period of visual development, because of a lack of sufficient plasticity in the adult brain.

Summary New treatments for amblyopia in children and adults are desirable and should be encouraged. However, further studies should be completed before such therapies are widely accepted into clinical practice.

aPediatric Ophthalmology and Ocular Genetics, Wills Eye Hospital, Philadelphia, Pennsylvania, USA

bEye Clinic, DiNOGMI, University of Genoa, Genoa, Italy

Correspondence to Dr Leonard B. Nelson, MD, Pediatric Ophthalmology and Ocular Genetics, Wills Eye Hospital, 840 Walnut Street, Suite 1210, Philadelphia, PA 19107-5109, USA. Tel: +1 877 289 4557; fax: +1 215 928 3983; e-mail:

Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.