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Recent advancements in diabetic retinopathy treatment from the Diabetic Retinopathy Clinical Research Network

Baker, Carl W.; Jiang, Yi; Stone, Thomas

Current Opinion in Ophthalmology: May 2016 - Volume 27 - Issue 3 - p 210–216
doi: 10.1097/ICU.0000000000000262
RETINAL, VITREOUS AND MACULAR DISORDERS: Edited by Brandon G. Busbee and John W. Kitchens

Purpose of review Diabetic retinopathy and diabetic macular edema (DME) are common eye diseases leading to vision loss. The Diabetic Retinopathy Clinical Research Network (DRCRnet), a collaboration of private and academic practices supported by the National Eye Institute and the National Institute of Diabetes, Digestive and Kidney Diseases has studied diabetic eye disease for 13 years. This review will discuss the network's findings over the last year, when some of its most important contributions were reported.

Recent findings The DRCRnet reported intravitreal bevacizumab, ranibizumab and aflibercept all improve visual acuity in DME. With baseline vision of 20/30 to 20/40, all agents had similar efficacy. With baseline vision of 20/50 or worse, aflibercept resulted in superior visual improvement. Protocol S, which compared panretinal photocoagulation with intravitreal injections of ranibizumab for proliferative diabetic retinopathy (PDR), found vision outcomes and surgery rates were not inferior in the injection group. Secondary outcomes indicate improved functional results with ranibizumab supporting injections as a possible alternative treatment for PDR.

Summary The DRCRnet has helped clarify the role of various treatments for both DME and PDR, and will continue to evaluate treatments for these vision-threatening conditions.

aPaducah Retinal Center, Paducah

bRetina Associates of Kentucky, Louisville, Kentucky, USA

Correspondence to Carl W. Baker, MD, Paducah Retinal Center, Paducah Kentucky 4630 Village Square Dr, Suite 102, Paducah, KY 42001, USA. Tel: +270 443 4393; fax: +270 443 7779; e-mail:

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