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Optical coherence tomography platforms and parameters for glaucoma diagnosis and progression

Mwanza, Jean-Claude; Budenz, Donald L.

Current Opinion in Ophthalmology: March 2016 - Volume 27 - Issue 2 - p 102–110
doi: 10.1097/ICU.0000000000000231
GLAUCOMA: Edited by Donald L. Budenz

Purpose of review Optical coherence tomography (OCT) aids in the diagnosis and long-term monitoring of various ocular diseases, including glaucoma. Initially, the retinal nerve fiber layer was the only OCT structural parameter used in glaucoma. Subsequent research has resulted in more retinal and optic nerve head parameters. In addition, OCT is being investigated for its ability to assess ocular hemodynamics. This review summarizes these spectral domain-optical coherence tomography (SDOCT) parameters in the context of glaucoma.

Recent findings Several new SDOCT retinal nerve fiber layer, optic nerve head, and macular parameters with good glaucoma diagnostic ability have been added to existing ones recently. The combination of SDOCT and Doppler or angiography has also resulted in hemodynamic parameters that may prove to be useful in the functional assessment in glaucoma.

Summary OCT technology is advancing not only as a tool for structural assessment, but also as a multimodality tool to assess both structure and function to enhance our understanding of glaucoma, and ultimately clinical decisions.

Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Correspondence to Jean-Claude Mwanza, Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, 130 Mason Farm Road, 5151 Bioinformatics Bldg, CB #7040, NC 27599, USA. Tel: +919 843 4917; fax: +919 966 1907; e-mail:

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