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Recent advances on ocular Demodex infestation

Cheng, Anny M.S.a,b,c; Sheha, Hosama,b,c; Tseng, Scheffer C.G.a,b,c

Current Opinion in Ophthalmology: July 2015 - Volume 26 - Issue 4 - p 295–300
doi: 10.1097/ICU.0000000000000168

Purpose of review To summarize recent advances on ocular Demodex infestation.

Recent findings Demodex infestation is a potential cause of ocular surface inflammation. The pathogenesis of Demodex in eliciting ocular surface inflammation has been further clarified. Cliradex is currently the treatment of choice, it comprises the most active ingredient of tea tree oil, that is terpinen-4-ol, which helps eradicate Demodex mites and reduce ocular surface inflammation.

Summary Ocular demodicosis is a common but overlooked eye disease that manifests a number of morbidities. Demodex folliculorum causes chronic anterior blepharitis whereas Demodex brevis causes posterior blepharitis, meibomian gland dysfunction, recurrent chalazia, and refractory keratoconjunctivitis. The lash sampling and microscopic counting method and in-vivo confocal microscopy are key diagnostic methods. Cliradex shows promising potential to reduce Demodex counts with additional antibacterial, antifungal, and anti-inflammatory actions.

aOcular Surface Center

bOcular Surface Research Education Foundation

cTissueTech, Inc., Miami, Florida, USA

Correspondence to Scheffer C.G. Tseng, MD, PhD, Ocular Surface Center, 7000 SW 97 Avenue, Suite 213. Miami, FL 33173, USA. Tel: +1 305 274 1299; fax: +1 305 274 1297; e-mail:

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