Ocular manifestations of systemic disease: Edited by Russell W. ReadOcular manifestations of systemic disease: ocular parasitosisRathinam, Sivakumar R; Ashok, Kawali AAuthor Information Aravind Eye Hospital & PG Institute of Ophthalmology, Madurai, Tamil Nadu, India Correspondence to Professor Sivakumar R. Rathinam, MNAMS, PhD, Aravind Eye Hospital & PG Institute of Ophthalmology, 1 Anna Nagar, Madurai 625 020, Tamil Nadu, India Tel: +91 452 4356123; fax: +91 452 2530984; e-mail: [email protected], URL: www.aravind.org Current Opinion in Ophthalmology: November 2010 - Volume 21 - Issue 6 - p 478-484 doi: 10.1097/ICU.0b013e32833ef67e Buy Metrics Abstract Purpose of review To highlight recent advances in basic research, diagnostic as well as therapeutic advances in ocular parasitosis and to evaluate their application in medical practice. Recent findings Knowledge relating to immunoreactivity in ocular parasitology has grown impressively in past few years. The outcome of infection is the result of a set of interactions involving host and parasite genetic background, environmental and social factors. Immunopathogenesis of parasite-mediated host cell lysis is better understood. Studies on newer drugs with cophylogenetic techniques are in horizon. There are success stories on control of transmission in some countries. Summary Much has been achieved; however, much more effort is needed in the area of translational research from bench to bedside. There is a need to enhance the awareness of risk factors of parasitic diseases in the population. Newer molecular diagnostic techniques need to be standardized for field application. Steps needed to be taken by the ophthalmologist when a parasite is seen in ocular tissues including identification, search for systemic involvement, treatment for elimination and sequelae and public health notification. Lack of methodological uniformity in management emphasis the need for standardization including construction of management algorithm for ophthalmologists. © 2010 Lippincott Williams & Wilkins, Inc.