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The treatment of branch retinal vein occlusion with bevacizumab

Badalà, Federico

Current Opinion in Ophthalmology: May 2008 - Volume 19 - Issue 3 - p 234–238
doi: 10.1097/ICU.0b013e3282fb7fb0
Retinal, vitreous and macular disorders: Edited by Gary C. Brown

Purpose of review New treatment modalities for branch retinal vein occlusion have recently been introduced. The role of intravitreal bevacizumab injections will be discussed and compared with laser photocoagulation and other novel intravitreal pharmacotherapies.

Recent findings Argon laser photocoagulation is the single treatment for branch retinal vein occlusion that has been shown to reduce vision loss in a randomized controlled clinical trial. The effectiveness of this treatment is limited though. Currently, increasing data support the role of intravitreal bevacizumab as an effective treatment for patients with macular edema secondary to branch retinal vein occlusion. Multiple injections seem to be necessary in order to achieve visual stabilization, favorable and durable macular changes. The effect of a single injection seems to last 6–8 weeks. The most common treatment protocol is two to three injections over the first 5–6 months. Patients who had minimal or no response to laser therapy appeared to benefit from bevacizumab. No significant complications have been associated with its use but only short-term data are available.

Summary Intravitreal bevacizumab appears to be a safe and effective treatment for macular edema associated with branch retinal vein occlusion, at least in the short term. Further randomized, controlled investigations are needed to assess long-term safety and efficacy of intravitreal bevacizumab.

Microchirurgia Oculare del Mediterraneo & Associati (MOMA), Rome, Italy

Correspondence to Federico Badala, MD, Microchirurgia Oculare del Mediterraneo & Associati (MOMA), Via Angelo Brofferio 7, Roma 00195, Italy Tel: +39 349 8712525; fax: +39 06 3725242; e-mail:

© 2008 Lippincott Williams & Wilkins, Inc.