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Review of recent publications of the Advanced Glaucoma Intervention Study

Beck, Allen D. MD

Current Opinion in Ophthalmology: April 2003 - Volume 14 - Issue 2 - p 83-85

Purpose of review This review summarizes and evaluates the published reports of the Advanced Glaucoma Intervention Study (AGIS) in the years 2001and 2002. AGIS evaluated two treatment sequences in medically uncontrolled open-angle glaucoma. Notable initial findings of AGIS included the presence of a race-treatment interaction for the treatment sequences of argon laser trabeculoplasty and trabeculectomy, and that lower intraocular pressures were associated with a reduced progression of visual field damage.

Recent findings More recent findings of AGIS include (1) confirmation and quantification of an increased risk of cataract formation following trabeculectomy; (2) identification of risk factors for failure of argon laser trabeculoplasty and trabeculectomy, and the impact of complications on the success of these treatments; and (3) further delineation of a differential response to surgical treatment between black and white patients.

Summary AGIS publications in 2001 and 2002 provide new information regarding the complications and outcomes of surgically treated open-angle glaucoma.

Department of Ophthalmology, Emory University, Atlanta, Georgia, USA.

Correspondence to Allen D. Beck, MD, Department of Ophthalmology, 1365-B Clifton Rd, N.E., Atlanta, GA 30322, USA; e-mail:

Supported, in part, by an unrestricted grant from Research to Prevent Blindness, Inc., New York, New York and P30 EYO6360 (a National Institutes of Health Departmental Core Grant, Bethesda, Maryland, USA).

© 2003 Lippincott Williams & Wilkins, Inc.