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Collaborative Normal Tension Glaucoma Study

Anderson, Douglas R. MD

Current Opinion in Ophthalmology: April 2003 - Volume 14 - Issue 2 - p 86-90

Purpose of review Before this study was done, there was a difference of opinion concerning whether intraocular pressure (IOP) was involved in producing optic nerve damage when there was glaucomatous damage to the optic nerve and characteristic visual field loss, even though the IOP was in the statistically normal range. This article reviews the findings of a collaborative study aimed at finding the answer to this question.

Recent findings The level of pressure influences the course of normal tension glaucoma, as evidenced by a slower rate of incident visual field loss in cases with 30% or more lowering of intraocular pressure. The rate of progression without treatment is highly variable, but often slow enough that half of the patients have no progression in 5 years. A faster rate occurs in women, in patients with migraine headaches, and in the presence of disc hemorrhages. Some patients may experience greater benefit from lowering of IOP than others, but further research is needed to be able to identify those most likely to benefit.

Summary As a group, patients with normal tension glaucoma benefit from lowering of IOP. Variable rate of deterioration, as well as lack of progression in a substantial number in 5 years, suggest that treatment should be individualized according to the stage of disease and rate of progression. Traits that help predict risk and rate of progression and response to treatment are beginning to become known and, when fully known, will help guide management decisions.

Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami, Florida, U.S.A.

This study was funded by the Glaucoma Research Foundation, San Francisco, California, with special grants from the Oxnard Foundation and the Edward J. Daly Foundation, San Francisco, California.

Correspondence to Douglas R. Anderson, M.D., Professor of Ophthalmology and Douglas R. Anderson Chair in Ophthalmology, Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, 900 NW 17 Street, Miami, FL, or PO Box 016880, Miami, FL 33101-6880; e-mail:

© 2003 Lippincott Williams & Wilkins, Inc.