Cancer biology: Edited by Christoph LengauerIntegrative oncogenomic approaches for accelerated cancer-gene discoveryZender, Larsa; Lowe, Scott Wa,bAuthor Information aCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA bHoward Hughes Medical Institute, Cold Spring Harbor, New York, USA Correspondence to Lars Zender, MD, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor NY 11724, USA Tel: +1 516 367 8408; e-mail: firstname.lastname@example.org Current Opinion in Oncology: January 2008 - Volume 20 - Issue 1 - p 72-76 doi: 10.1097/CCO.0b013e3282f31d5d Buy Metrics Abstract Purpose of review The completion of the human genome project has enabled several new technologies for studying cancer genetics and cancer genomes. However, genomic instability and heterogeneity of human tumors impedes a straightforward cataloging of cancer genes and possible therapeutic targets. Strategies enabling the distinction of causal genetic alterations from bystander genomic noise are needed and should significantly speed up the process of cancer-gene discovery. Recent findings A series of recent papers described the development of integrative oncogenomic approaches based on innovative cancer mouse models and how these can be used to speed up the discovery of new cancer genes. In the presented studies, spontaneously acquired genetic alterations in mouse tumors of defined genetic origin are used to filter/prioritize relevant lesions from complex human cancer genomes. As will be discussed in this review, a great advantage of this approach is that pinpointed candidate genes can be functionally validated in the right genetic context in vivo, which significantly increases confidence for later therapeutic development efforts. Summary The discussed approaches hold great promise to speed up the process of cancer-gene discovery and should be considered to complement time-consuming and costly endeavors like the Cancer Genome Project. © 2008 Lippincott Williams & Wilkins, Inc.