HEAD AND NECK: Edited by Joel GuigayHow to prevent human papillomavirus-related oropharyngeal cancer?Ferrando-Díez, Angelicaa; Pavón, Miguel Angelb,c; Cirauqui, Beatriza; Alemany, Laiab,c; Mesía, Ricarda Author Information aMedical Oncology Department, Catalan Institute of Oncology-Badalona (ICO), Applied Research Group in Oncology (B-ARGO), IGTP, 08916 Badalona bCancer Epidemiology Research Program, Catalan Institute of Oncology (ICO)-IDIBELL, L’Hospitalet de Llobregat, 08908 Barcelona cCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain Correspondence to Angelica Ferrando-Díez, Carretera de Canyet s/n, 08916 Badalona, Barcelona, Spain. Tel: +34-93-497-8925; e-mail: [email protected] Current Opinion in Oncology 35(3):p 145-150, May 2023. | DOI: 10.1097/CCO.0000000000000937 Buy Metrics Abstract Purpose of review Human papillomavirus (HPV) is responsible of the increasing incidence rates of oropharyngeal squamous cell carcinoma (OPSCC) in high-income countries. This significant epidemiological change requires several and diverse prevention strategies. Recent findings The cervical cancer prevention model is the paradigm of HPV-related cancer, and its success provides encouragement for the development of similar methods to prevent HPV-related OPSCC. However, there are some limitations that hinder its application in this disease. Here, we review the primary, secondary and tertiary prevention of HPV-related OPSCC and discuss some directions for future research. Summary The development of new and targeted strategies to prevent HPV-related OPSCC is needed since they could definitely have a direct impact on the reduction of morbidity and mortality of this disease. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.