ENDOCRINE TUMORS: Edited by Christiane JungelsMolecular genotyping in medullary thyroid cancerNewbold, Kate Author Information The Royal Marsden NHS Foundation Trust Hospital, London, UK Correspondence to Kate Newbold, Consultant Clinical Oncologist, The Royal Marsden NHS Foundation Trust Hospital, Fulham Road, London SW3 6JJ. UK. Tel: +44 2078082125; e-mail: [email protected] Current Opinion in Oncology 35(1):p 10-14, January 2023. | DOI: 10.1097/CCO.0000000000000915 Buy Metrics Abstract Purpose of review There has been a significant advance in our understanding of the molecular biology of medullary thyroid cancer (MTC) alongside progress in the development of targeted therapies including multikinase and specific rearranged during transfection inhibitors. Recent findings This review will examine the latest data investigating the impact of the genomics of MTC on the prediction of the natural history of an individual's disease and the determination, selection and timing of treatment interventions. Summary Recent advances in genotyping in MTC and the development of targeted therapies have impacted on the clinical management of both sporadic and hereditary MTC. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.