LYMPHOMA: Edited by Dominique BronHairy cell leukemia: a brief update on current knowledge and treatment prospectsPuła, Anna; Robak, Tadeusz Author Information Department of Hematology, Medical University of Lodz, Lodz, Poland Correspondence to Tadeusz Robak, Department of Hematology, Medical University of Lodz, Copernicus Memorial Hospital, Ul. Ciolkowskiego 2, 93-510 Lodz, Poland. Tel: +48 42 689 51 91; fax: +48 42 689 51 92; e-mail: [email protected] Current Opinion in Oncology: September 2021 - Volume 33 - Issue 5 - p 412-419 doi: 10.1097/CCO.0000000000000771 Buy Metrics Abstract Purpose of review This article provides a brief update on the recommended diagnosis and treatment strategies for patients with the classic form of hairy cell leukemia (HCL) and HCL variant (HCLv). Recent findings HCL is a chronic B-cell malignancy with multiple treatment options. In recent years, many novel drugs have been assessed for HCL treatment with promising results. The investigated nonchemotherapy options include moxetumomab pasudotox, which targets CD22; vemurafenib or dabrafenib, which target the BRAFV600E protein; trametinib, which targets mitogen-activated protein kinase enzyme; and ibrutinib, which targets Bruton tyrosine kinase. Summary Purine analogs significantly improve survival in patients with HCL. However, patients often relapse, require multiple treatments, and may become refractory. The introduction of novel agents has expanded the spectrum of therapy possibilities in those patients. In the coming years, they will assist standard therapy for patients with HCL who may currently have suboptimal results. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.