BRAIN AND NERVOUS SYSTEM: Edited by Marc SansonMechanisms of invasion in glioblastomaChouleur, Tiffaniea,b,c; Tremblay, Michel L.b,c,d; Bikfalvi, AndreasaAuthor Information aUniversity Bordeaux, INSERM, LAMC, U1029, F-33600 Pessac, France bRosalind and Morris Goodman Cancer Research Center cDepartment of Medicine, Division of Experimental Medicine dDepartment of Biochemistry, McGill University, Montreal, Quebec, Canada Correspondence to Andreas Bikfalvi, MD, PhD, University Bordeaux, LAMC, Bordeaux, France. E-mail: [email protected] Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.co-oncology.com). Current Opinion in Oncology: November 2020 - Volume 32 - Issue 6 - p 631-639 doi: 10.1097/CCO.0000000000000679 Buy SDC Metrics Abstract Purpose of review This review provides an overview of recent updates in understanding the mechanisms by which glioblastoma cells interact with their cellular and molecular partners within the microenvironment. Recent findings We have now a better knowledge of the cell populations involved in Glioblastoma (GBM) invasion. Recent works discovered the role of new molecular players in GBM invasion, and, most importantly, better models are emerging which better recapitulate GBM invasion. Summary Invasive properties of glioblastoma make complete surgical resection impossible and highly invasive cells are responsible for tumor recurrence. In this review, we focus on recent updates describing how invasive cells progress in the surrounding tissue along brain structures. We also provide an overview of the current knowledge on key cells and molecular players within the microenvironment that contribute to the invasive process. https://links.lww.com/COON/A28 Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.