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The close interrelation between colorectal cancer, infection and microbiota

Massaut, Edouarda; Hendlisz, Barbarab; Klastersky, Jean A.b

doi: 10.1097/CCO.0000000000000543
GASTROINTESTINAL TRACT: Edited by Alain Hendlisz

Purpose of review Evaluate the recent literature about the relation of clinical infection and colorectal cancer in terms of diagnosis of an occult infection and possible impact on oncological outcome and review the possible role of the gut microbiota in the role of colorectal cancer oncogenesis.

Recent findings Data published within the 2 last years have been reviewed and the conclusions, mostly supporting previously published information, have been critically discussed.

Summary Infection (bacteremia, cellulitis) might be a surrogate of occult colorectal cancer and postoperative infection complications might jeopardize long-term survival after potentially curative surgery. The role of the gut microbiota in the genesis of colorectal cancer remains an exciting though unresolved question.

aService de Chirurgie, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg

bService d’Oncologie Médicale, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium

Correspondence to Edouard Massaut, MD, Service de Chirurgie, Centre Hospitalier de Luxembourg, Rue Barblé, 4, 1210 Luxembourg, Luxembourg. Tel: +352 44 11 2085; e-mail:

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