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T lymphocytes as therapeutic arsenal for patients with hematological malignancies

Montoro, Juana; Piñana, José L.a,b; Sanz, Jaimea,b; Guerreiro, Manuela

doi: 10.1097/CCO.0000000000000481

Purpose of review We present an overview of the clinically available immunotherapeutic platforms centered on T cell lymphocytes for the treatment of hematological malignancies with a special focus on the advances achieved since 2017.

Recent findings The most promising strategies of T cell therapies are based on the infusion of unmanipulated donor lymphocytes, antigen-specific T cells, ex-vivo genetically modified T cells or in-vivo manipulation of T cells using antibodies (bispecific and checkpoint inhibitors). To select the most appropriate option for a specific patient, is important to understand not only each platform-specific biological mechanisms, clinical activity and toxicities but also their intrinsic differences. In this extremely fast-growing field, to keep track of recent advances is a hard and challenging task for a hematologist. Therefore, we aimed to provide a global integrative review of T-cell-based immunotherapies, essential to ascertain their optimal place and timing in our daily clinical practice.

Summary We highlight recent advances and discuss future directions of T-cell-based immunotherapies entering the common clinical practice in hematology.

aTransplant Unit, Department of Hematology, Hospital Universitario y Politécnico La Fe, Valencia

bCIBERONC, Instituto de Salud Carlos III, Madrid, Spain

Correspondence to Manuel Guerreiro, Transplant Unit, Department of Hematology, Hospital Universitario y Politécnico La Fe, Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain. Tel: +34 961 24 58 75; fax: +34 961 24 62 01; e-mail:

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