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Put away your microscopes: the ependymoma molecular era has begun

Mack, Stephen C.a,b; Taylor, Michael D.c

doi: 10.1097/CCO.0000000000000411
Editor's Choice

Purpose of review To synthesize, integrate, and comment on recent research developments to our understanding of the molecular basis of ependymoma (EPN), and to place this in context with current treatment and research efforts.

Recent findings Our recent understanding of the histologically defined molecular entity EPN has rapidly advanced through genomic, transcriptomic, and epigenomic profiling studies.

Summary These advancements lay the groundwork for development of future EPN biomarkers, models, and therapeutics. Our review discusses these discoveries and their impact on our clinical understanding of this disease. Lastly, we offer insight into clinical and research areas requiring further validation, and open questions remaining in the field.

aDepartment of Pediatrics, Baylor College of Medicine

bDepartment of Pediatric Hematolgy and Oncology, Texas Children's Cancer and Hematology Centers, Houston, Texas, USA

cDivision of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada

Correspondence to Dr Michael D. Taylor, The Hospital for Sick Children, 555 University Ave. Rm 1504, Toronto, ON, Canada M5G 1X8. Tel: +1 416 813 7564; e-mail:

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