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Three molecular determinants of malignant conversion and their potential as therapeutic targets

Dome, Jeffrey S. MD; Look, A. Thomas MD

Current Opinion in Oncology: January 1999 - Volume 11 - Issue 1 - p 58
Cancer Biology

The past decade has been marked by an explosion of knowledge regarding the dysregulation of cancer at the molecular level. It has become apparent that oncogenes, tumor suppressor genes, and other ancillary molecules interact in complex pathways that govern cellular homeostasis. We review three molecular events that have been implicated in tumorigenesis and define pathways ripe for the development of new therapeutic approaches: 1) activation of telomerase, 2) dysregulation of the patched/sonic hedgehog pathway, and 3) mutation of the INK4α-ARF locus.

St. Jude Children’s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105-2794, USA.

© 1999 Lippincott Williams & Wilkins, Inc.