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Recent advances in systemic therapy for gastrointestinal neuroendocrine tumors

Pelley, Robert J. MD; Bukowski, Ronald M. MD

Current Opinion in Oncology: January 1999 - Volume 11 - Issue 1 - p 32
Endocrine Tumors

Neuroendocrine tumors of the gastrointestinal tract are rare tumors which can be classified as amine precursor uptake and decarboxylation tumors (APU-Domas). Although the majority of clinically apparent tumors are malignant, they are frequently slow growing. Despite this characteristic, they may generate disabling hormonal syndromes requiring aggressive treatment to achieve palliation. Recent advances in understanding the pathophysiology of these tumors has led to better medical therapy with chemotherapeutic agents, somatostatin analogues, and biologic therapies. This review will update the recent efforts in systemic therapies of the gastrointestinal neuroendocrine tumors.

Department of Hematology and Medical Oncology, The Cleveland Clinic Foundation, Desk T40, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA.

© 1999 Lippincott Williams & Wilkins, Inc.