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Dalla-Favera Riccardo MD; Gu, Wei; Tassi, Vittorio MD; Cechova, Katarina MD
Current Opinion in Oncology: December 1992
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The precise effect of chromosomal translocations involving the c-myc proto-oncogene in lymphomagenesis is unknown due to limited knowledge of the function of the c-Myc protein. Recent results suggest that c-Myc can function as a transcriptional regulator in heterodimeric complexes with the related protein Max and that opposite regulation of target gene expression and cell proliferation can be obtained by using a differential assortment of c-Myc—Max complexes.

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