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de Thé Hugues PhD; Chomienne, Christine PhD; Degos, Laurent PhD; Dejean, Anne PhD
Current Opinion in Oncology: December 1992
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Acute promyelocytic leukemia (APL) is characterized by both an exquisite retinoic acid sensitivity and a specific t(15,17) translocation. The translocation generates a disease-specific promyelocytic leukemia (PML)—retinoic acid receptor (RAR)α fusion protein, between a putative transcription factor (PML) and the RARα, which is likely to be involved in differentiation arrest and transformation. Although the molecular basis of APL retinoic acid sensitivity is not understood, APL is the first example of a treatment specifically targeted at a genetic lesion in a human malignancy.

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