REVIEWAlarming trends and disparities in high-risk endometrial cancerEakin, Cortney M.a; Lai, Tiffanya; Cohen, Joshua G.b Author Information aDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of California, Los Angeles bDivision of Gynecologic Oncology, Department of Surgery, City of Hope, Irvine, California, USA Correspondence to Joshua G. Cohen, MD, 1000 FivePoint, Irvine, CA 92618, USA. E-mail: [email protected] Current Opinion in Obstetrics and Gynecology: October 14, 2022 - Volume - Issue - 10.1097/GCO.0000000000000832 doi: 10.1097/GCO.0000000000000832 Buy PAP Metrics Abstract Purpose of review To summarize the most recent publications highlighting the trends and disparities among patients diagnosed with high-risk endometrial cancer. Recent findings Endometrial cancer mortality continues to rise, driven by the increasing incidence of high-risk histologic subtypes that accounts for a disproportionate number of endometrial cancer deaths. The lack of progress made in endometrial cancer treatment, particularly of high-risk histologic subtypes, disproportionately affects black women who are more likely to be diagnosed with these aggressive tumor types. Even when accounting for high-risk histology, various factors across the spectrum of care may influence the survival disparities between black and white women, including timely access to guideline-concordant care, clinical trial enrollment, and systemic racism that impacts cancer outcomes. Summary In this review, we highlight the disproportionate impact of worsening endometrial cancer mortality and healthcare inequalities contributing to the endometrial cancer survival disparity between black and white women. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.