FAMILY PLANNING: Edited by Paul D. BlumenthalManagement of bothersome bleeding associated with progestin-based long-acting reversible contraception: a reviewHenkel, Andrea; Goldthwaite, Lisa M.Author Information Division of Family Planning Services & Research, Department of Obstetrics & Gynecology, Stanford University, Stanford, California, USA Correspondence to Andrea Henkel, MD, 300 Pasteur Drive, Room HG332, Stanford, CA 94305, USA. Tel: +1 651 402 4324; e-mail: [email protected] Current Opinion in Obstetrics and Gynecology: December 2020 - Volume 32 - Issue 6 - p 408-415 doi: 10.1097/GCO.0000000000000664 Buy Metrics Abstract Purpose of review To describe common bleeding patterns and treatment strategies to minimize bothersome bleeding in users of progestin-based long-acting reversible contraception (LARC). Recent findings Most levonorgestrel intrauterine device users will establish a favorable bleeding pattern within a year; NSAIDs are the most effective bridge to help with bothersome bleeding during that time period. Early follicular phase insertion and fundal placement are associated with more favorable early bleeding profiles. Recent studies exploring tranexamic acid, mifepristone, and tamoxifen's adjunct role show modest or no benefit. The progestin implant is associated with more persistent unpredictable bleeding disproportionately affecting women with higher etonogestrel serum levels; recent studies indicate that oral contraceptives, ulipristal acetate, and tamoxifen may all provide temporary relief. Summary Women's healthcare providers can offer patients adjunct medical therapies to minimize bothersome bleeding associated with progestin LARC use, which may result in increased satisfaction and continuation rates of these effective forms of contraception. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.