WOMEN'S HEALTH: Edited by Joseph AquilinaVitamin D supplementation during pregnancy: an overviewPérez-López, Faustino R.a; Pilz, Stefanb; Chedraui, Peterc,dAuthor Information aInstituto de Investigación Sanitaria de Aragón and University of Zaragoza Faculty of Medicine, Zaragoza, Spain bDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria cInstituto de Investigación e Innovación en Salud Integral, Facultad de Ciencias Médicas, Universidad Católica de Santiago de Guayaquil, Guayaquil, Ecuador dFacultad de Ciencias de la Salud, Universidad Católica Nuestra Señora de la Asunción, Asunción, Paraguay Correspondence to Faustino R. Pérez-López, MD, PhD, Department of Obstetrics and Gynecology, University of Zaragoza Faculty of Medicine, Zaragoza 50009, Spain. Tel: +34 976 761734; fax: +34 976 761735; e-mail: [email protected] Current Opinion in Obstetrics and Gynecology: October 2020 - Volume 32 - Issue 5 - p 316-321 doi: 10.1097/GCO.0000000000000641 Buy Metrics Abstract Purpose of review Examine recent evidence of randomized controlled trials and meta-analyses regarding the effect of maternal vitamin D status and supplementation over obstetrical and offspring outcomes. Recent findings Maternal serum 25-hydroxyvitamin [25(OH)D] progressively declines during pregnancy because of fetal physiological demands and adjustments. Vitamin D supplementation during pregnancy in women with low vitamin D status may improve fetal growth and reduce the risks for small-for-gestational-age, preeclampsia, preterm birth, and gestational diabetes. Mothers with sufficient vitamin D levels have offsprings with less enamel defects and less attention deficit and hyperactive disorders and autism. All pregnant women should be supplemented with 600 IU/day of vitamin D3. We discuss evidence indicating that higher vitamin D doses (1000–4000 IU/day) may be convenient to achieve better maternal and infant outcomes. Low maternal vitamin D status during pregnancy may be associated in infants with a higher risk for lower bone mineral content, enamel defects and attention deficit hyperactive disorder. Summary Recent evidence from vitamin D intervention studies and meta-analyses of a large number of studies support vitamin D supplementation during pregnancy to improve maternal, fetal and, immediate and later offspring health. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.