Corynebacterium kroppenstedtii is a difficult pathogen associated with granulomatous mastitis and recurrent breast abscesses. Despite over a dozen studies, there is no guidance on surgical interventions, steroid use, or dosing or duration of antibiotic treatment.
Initially seen in predominantly Maori and Pacific Islander multiparous, postlactating women, C. kroppenstedtii breast infection has since been reported throughout the world, including in nulliparous women. Additionally, emerging data suggest that hyperprolactinemia is a modifiable risk factor for these infections. This article reviews a patient case and data from 87 other cases to compile current best practices for diagnosis, treatment, and monitoring, and provides areas for future study.
In cases of granulomatous mastitis and breast abscess, especially if recurrent, infection with C. kroppenstedtii should be considered. Microbiologists should be alerted to the specialized growth conditions and tools needed for appropriate culturing, identification, and antibiotic susceptibility testing. Clinicians should utilize a multimodal approach with surgical and antibiotic treatment to maximize clinical cure and reduce recurrence.
aDepartment of Pharmacy, Montefiore Medical Center, Wakefield Division
bDepartment of Medicine (Infectious Diseases), Albert Einstein College of Medicine, Bronx, New York, USA
Correspondence to Nidhi Saraiya, Montefiore Medical Center, Wakefield Division, Department of Pharmacy, 600 East 233rd Street, Bronx, NY 10466, USA. Tel: +1 732 675 2696; e-mail: firstname.lastname@example.org