FERTILITY, IVF AND REPRODUCTIVE GENETICS: Edited by Emre Seli and Juan A. García VelascoEndocrine and reproductive profile of boys and young adults conceived after ICSIBelva, Florencea; Bonduelle, Marysea; Tournaye, HermanbAuthor Information aCenter for Medical Genetics bCenter for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium Correspondence to Florence Belva, MD, PhD, Center for Medical Genetics, Universitair Ziekenhuis Brussel, Brussels, Belgium. Tel: +32 2 477 60 71; e-mail: [email protected] Current Opinion in Obstetrics and Gynecology: June 2019 - Volume 31 - Issue 3 - p 163-169 doi: 10.1097/GCO.0000000000000538 Buy Metrics Abstract Purpose of review The impact of intracytoplasmic sperm injection (ICSI), on the reproductive health of the offspring is largely unknown. Here we provide a comprehensive overview of the endocrine and reproductive profile in boys and young male adults born after ICSI using ejaculated spermatozoa alleviating male factor infertility in their parents. Recent findings Levels of testosterone, anti-Müllerian hormone and inhibin B were found comparable in prepubertal and pubertal boys conceived by ICSI when compared with levels in boys conceived spontaneously. Also, at young adulthood, mean levels of reproductive hormones did not differ from control peers. However, semen analysis showed significantly lower sperm concentration, total sperm count and total motile sperm count when compared with controls. Furthermore, the risk of having sperm concentration and sperm count below the reference values was increased in ICSI offspring while sperm parameters did not correlate in paired father-son semen analysis. Summary Although endocrine gonadal function was normal at puberty, exocrine function at young adulthood was not. We observed decreased semen quality and quantity in young adults conceived by ICSI performed to circumvent male factor infertility. The possibility of transgenerational transmission of impaired spermatogenesis after ICSI needs further investigation. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.