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Recent advances in gynecologic radiation oncology

Venkat, Puja S.; Parikh, Neil; Beron, Phillip

Current Opinion in Obstetrics and Gynecology: February 2019 - Volume 31 - Issue 1 - p 38–42
doi: 10.1097/GCO.0000000000000519
GYNECOLOGIC CANCER: Edited by Gottfried E. Konecny
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Purpose of review Radiation has long been a primary treatment modality in locally advanced gynecologic carcinomas and a tool for palliation of metastatic disease. Here we review advances in imaging and radiation technologies and the corresponding clinical evolution of the role for radiation oncology in the treatment of gynecologic malignancies.

Recent findings Advances in MRI are impacting diagnosis, radiation target delineation, planning, treatment delivery, and response assessment. The combination of MRI and PET-computed tomography (PET-CT) has the potential to significantly change treatment recommendations as compared with a single imaging modality. Advances in radiation delivery including intensity modulated radiation therapy (IMRT) and stereotactic ablative radiotherapy (SABR) have expanded the role for radiation in the definitive treatment of high risk and oligometastatic ovarian cancer. Finally, global disparities in oncology resources has led to the development of resource stratified treatment guidelines for gynecologic malignancies. The use of ultrasound for brachytherapy planning may help improve access to this critical treatment modality.

Summary As imaging and radiation technologies advance, the indications for radiation in the treatment of gynecologic malignancies continues to evolve. Here we review the changing landscape of radiation oncology in the multidisciplinary management of gynecologic cancers.

Department of Radiation Oncology, University of California, Los Angeles, USA

Correspondence to Phillip Beron, MD, Department of Radiation Oncology, University of California, 200 Medical Plaza, Suite B265, Los Angeles, CA 90095-6951, USA. Tel: +1 310 825 9771; fax: +1 310 794 9795; e-mail: pberon@mednet.ucla.edu

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