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Mitochondrial replacement therapy

Dougherty, Michael P.; Dolitsky, Shelley; Chattopadhyay, Rhea; Sauer, Mark V.

Current Opinion in Obstetrics and Gynecology: August 2018 - Volume 30 - Issue 4 - p 217–222
doi: 10.1097/GCO.0000000000000467

Purpose of review The present study briefly reviews the history of mitochondrial replacement therapy (MRT); however, the focus is on recent advancements and future directions of the field. Specifically addressing societal and legal concerns and advances in MRT.

Recent findings There continue to be new ethical debates surrounding MRT. In addition, there have been advancements in MRT techniques which could improve potential outcomes. Furthermore, advances in genetics continue to provide alternative approaches to treatment of many diseases, including alternatives to MRT.

Summary MRT may be beneficial to eradicate a severely debilitating and often fatal disease. Despite significant supporting safety and efficacy, there are still many social and legal barriers to instituting MRT to clinical practice.

Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA

Correspondence to Michael P. Dougherty, Department of OB/GYN, 2nd Floor, 125 Patterson St, New Brunswick NJ 08902, USA. Tel: +1 570 956 2507; fax: +1 732 235 9855; e-mail:,

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