Secondary Logo

Institutional members access full text with Ovid®

Metabolism of the oocyte and the preimplantation embryo: implications for assisted reproduction

Scott, Richard, III; Zhang, Man; Seli, Emre

Current Opinion in Obstetrics and Gynecology: June 2018 - Volume 30 - Issue 3 - p 163–170
doi: 10.1097/GCO.0000000000000455
FERTILITY, IVF AND REPRODUCTIVE GENETICS: Edited by Emre Seli and Juan A. García-Velasco
Buy
SDC

Purpose of review To discuss the common aspects of energy generation in the cell, substrate utilization by the oocyte and the preimplantation embryos, metabolic characteristics of the reproductive tract, and how metabolic characteristics of an embryo can be exploited to assess viability.

Recent findings Utilization of pyruvate, lactate and glucose by the oocyte and the preimplantation embryo seems to be tightly controlled by the most essential molecular regulatory pathways.

Summary Accumulating data on the metabolic needs of the preimplantation embryo and the substrate concentrations in the reproductive tract guide us in improving in-vitro culture conditions, and provide potential biomarkers of embryo viability.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, USA

Correspondence to Emre Seli, MD, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, 310 Cedar Street LSOG 304B, New Haven, CT 06520-8063, USA. Tel: +1 203 785 7873; fax: +1 203 785 7819; e-mail: emre.seli@yale.edu.

Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.