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Management of fibroids in perimenopausal women

Giannubilo, Stefano R.a; Ciavattini, Andreaa; Petraglia, Feliceb; Castellucci, Marioc,*; Ciarmela, Pasquapinac,d,*

Current Opinion in Obstetrics and Gynecology: December 2015 - Volume 27 - Issue 6 - p 416–421
doi: 10.1097/GCO.0000000000000219
WOMEN'S HEALTH: Edited by Joseph Aquilina

Purpose of review This article reviews fibroids management in the perimenopausal period, and addresses future directions in care.

Recent findings Aromatase inhibitors, selective estrogen receptor modulators and antiprogestogens for medical management and minimally surgical techniques are promising treatments.

Summary The disease and the symptoms may persist in the peri and postmenopausal periods. The assumption that they will resolve with the onset of the menopause is too simplistic and not always valid. The number of perimenopausal women who wish to retain their uterus for reasons other than childbearing is increasing. The accurate diagnosis of these conditions may result in minor surgical or medical treatments being directed at the specific pathology and may avoid the need for major surgery.

aDepartment of Clinical Science, Polytechnic University of Marche, Ancona

bDepartment of Molecular and Developmental Medicine, Obstetrics, and Gynecology, University of Siena, Siena

cDepartment of Experimental and Clinical Medicine, Faculty of Medicine

dDepartment of Information Engineering, Polytechnic University of Marche, Ancona, Italy

*Mario Castellucci and Pasquapina Ciarmela contributed equally to the writing of this article.

Correspondence to Pasquapina Ciarmela, PhD, Department of Experimental and Clinical Medicine, Faculty of Medicine, Polytechnic University of Marche, via Tronto 10/a, 60020 Ancona, Italy. Tel: +390712206270; fax: +390712206087; e-mail:

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