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The use of aromatase inhibitors for ovulation induction

Klement, Anat Hershkoa,b; Casper, Robert F.a,b

Current Opinion in Obstetrics and Gynecology: June 2015 - Volume 27 - Issue 3 - p 206–209
doi: 10.1097/GCO.0000000000000163
FERTILITY, IVF AND REPRODUCTIVE GENETICS: Edited by Emre Seli and Juan Antonio García Velasco

Purpose of review Approximately 15% of the infertile population faces an ovulatory disorder; most of them classified as WHO class two anovulation [polycystic ovarian syndrome (PCOS) prototype]. Worldwide, this translates into millions of patients and emphasizes the need of a simple, effective and well tolerated method of ovulation induction. In this review, we will revisit letrozole use in the subset of WHO class two ovulatory problems and evaluate the contribution of the last year's literature to its practice.

Recent findings In a multicentre, randomized controlled trial comparing letrozole with clomiphene in 750 PCOS patients having regular intercourse, live birth rates were significantly higher for the letrozole group [rate ratio 1.44, 95% confidence interval (95% CI) 1.10–1.87]. In a meta-analysis summarizing clinical trials testing aromatase inhibitors used alone or with other medical therapies for ovulation induction in PCOS patients, live birth rates were again significantly higher when letrozole was compared with clomiphene citrate [odds ratio (OR) 1.64, 95% CI 1.32–2.04]. A retrospective analysis of children born to infertile women assessed the congenital malformation rate after exposure to letrozole in comparison to clomiphene citrate and to natural conceptions. No significant differences in malformation rates were detected between the groups (2.9, 2.5 and 3.9%, respectively).

Summary High-level evidence supports letrozole as the first drug of choice for ovulation induction in the PCOS population. The increasing use of letrozole with pregnancy follow-up provides additional reassurance for foetal safety.

aDivision of Reproductive Sciences, Fran and Lawrence Bloomberg Department of Obstetrics and Gynecology, University of Toronto, The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital

bTCART Fertility Partners, Toronto, Ontario, Canada

Correspondence to Robert F. Casper, 150 Bloor Street West, Suite 210, Toronto, ON M5S 2X9, Canada. Tel: +1 416 972 0110; fax: +1 416 972 0036; e-mail:

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