PRENATAL DIAGNOSIS: Edited by James F. Smith Jr.Soft markers for aneuploidy following reassuring first trimester screening what should be done?Stefanovic, VedranAuthor Information Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland Corresponding to Vedran Stefanovic, A/Professor of Obstetrics, Gynecology and Fetomaternal Medicine, Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu 2, PL 140, 00029 HUS Helsinki, Finland. Tel: +358 50 427 1230; e-mail: firstname.lastname@example.org Current Opinion in Obstetrics and Gynecology: April 2015 - Volume 27 - Issue 2 - p 151-158 doi: 10.1097/GCO.0000000000000157 Buy Metrics Abstract Purpose of review The present article aims to review the current role of the soft markers on the second trimester ultrasound (STUS) in women after reassuring first trimester screening (FTS) in singleton pregnancies. Recent findings Improvements in the FTS and the recent implementation of noninvasive prenatal testing (NIPT) for common aneuploidies have important impact on the prevalence of these conditions in the STUS. Some studies suggest that soft markers in the second trimester of the fetus without structural anomalies have a minor or no role in Down syndrome detection in a prescreened population with reassuring results. However, NIPT could be offered as a next step in the management of such pregnancies if the calculated new composite risk (NCR) for aneuploidy is increased. In the case of reassuring results, pregnancy follow-up for certain markers is advised. Summary NIPT has emerged as a new method of prenatal testing and is feasible in the second trimester in women with increased NCR. However, apart from the Down syndrome screening, STUS screening remains a powerful tool in screening for other fetal aneuploidies, structural anomalies and pathological placental conditions and detection of specific soft markers that require pregnancy follow-up. Copyright © 2015 YEAR Wolters Kluwer Health, Inc. All rights reserved.