GYNECOLOGIC CANCER: Edited by Gottfried E. KonecnySentinel lymph node biopsy in the management of gynecologic cancerCibula, Davida; Oonk, Maaike H.M.b; Abu-Rustum, Nadeem R.c Author Information aGynecologic Oncology Center, Department of Obstetrics and Gynecology, General University Hospital, First Faculty of Medicine, Charles University, Prague, Czech Republic bDepartment of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands cGynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA Correspondence to David Cibula, Gynecologic Oncology Center, Department of Obstetrics and Gynecology, Apolinarska 18, Prague 2, 120 00, Czech Republic. Tel: +420 224967451; e-mail: [email protected] Current Opinion in Obstetrics and Gynecology: February 2015 - Volume 27 - Issue 1 - p 66-72 doi: 10.1097/GCO.0000000000000133 Buy Metrics Abstract Purpose of review To summarize current knowledge and recent advances in sentinel lymph node (SLN) concept in the three most frequent gynecological cancers. Recent findings In cervical cancer, SLN biopsy and ultrastaging has high sensitivity in lymph node staging in patients with bilaterally detected SLN. The presence of micrometastasis is associated with shortened survival. In endometrial cancer, SLN biopsy incorporating an institutional mapping algorithm and ultrastaging has been shown to significantly reduce false-negative rates and increase sensitivity and negative predictive value. Summary SLN biopsy and ultrastaging is useful in current management of patients with early-stage cervical cancer for multiple reasons, such as the reliable detection of key lymph nodes, identification of micrometastasis and intraoperative triage of patients. Although a complete or selective pelvic and paraaortic lymphadenectomy for adequate staging remains the standard treatment approach in patients with early-stage endometrial cancer, SLN biopsy has been shown to be safe and effective in detecting lymph node metastases. The application of the SLN procedure is safe in patients with early-stage unifocal squamous cell cancer of the vulva (<4 cm) and no suspicious enlarged lymph nodes at imaging. Copyright © 2015 YEAR Wolters Kluwer Health, Inc. All rights reserved.