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Time-lapse embryo imaging technology: does it improve the clinical results?

Findikli, Necatia; Oral, Enginb

Current Opinion in Obstetrics and Gynecology: June 2014 - Volume 26 - Issue 3 - p 138–144
doi: 10.1097/GCO.0000000000000072
FERTILITY: Edited by Aydin Arici

Purpose of review The purpose of the review is to summarize recent developments in time-lapse technologies and early embryo morphokinetics and to discuss their impact on current clinical outcomes.

Recent findings Contemporary embryo culture and selection methodologies that are based on classical morphology are clearly limited in providing the most suitable embryo for a successful pregnancy. Noninvasive observation of embryo development by capturing the images with a time-lapse device has recently been proposed to be a better method of embryo viability assessment. Such methodologies have been shown to increase the quality and the quantity of information on the viability without disturbing the culture conditions.

Summary Commercial availability of different time-lapse devices for human embryos facilitated the use of morphokinetics as an additional tool in human embryo selection. The application of such technologies has already shown positive results on clinical outcome by increasing our scope of traditional embryo selection, leading to higher implantation and clinical pregnancy rates. Additional benefit can come from the less-disturbed incubation environment that is created by all-in-one incubators. Such devices can also be very important research tools in order to observe and analyze the effect of different patient-specific or clinical conditions on embryo development parameters that are not available through classical embryo scoring.

aBahceci Fulya IVF Centre

bDivision of Reproductive Endocrinology, Department of Obstetrics and Gyneocology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey

Correspondence to Professor Dr Engin Oral, Vali Konagi Cad. Saroglu Apt. No: 83 Kat: 3 D: 10 Nisantasi, Istanbul, Turkey. Tel: +90212 343 20 00; 343 20 01; fax: +90212 343 20 02; e-mail:

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